Diclofenac - Generic Voltaren/Misoprostol is used for:

Treating joint swelling, pain, and stiffness caused by osteoarthritis or rheumatoid arthritis in patients who are at a high risk of developing NSAID-induced ulcers or their complications. It may also be used for other conditions as determined by your doctor.

Diclofenac - Generic Voltaren/Misoprostol is an NSAID and prostaglandin analog combination. The prostaglandin maintains prostaglandin activity needed to protect the lining of the stomach and reduce acid secretion, reducing the risk of ulcers. The NSAID decreases prostaglandins that cause pain and inflammation, relieving joint pain.

Do NOT use Diclofenac - Generic Voltaren/Misoprostol if:

• you are allergic to any ingredient in Diclofenac - Generic Voltaren/Misoprostol or other prostaglandins

• you are pregnant

• you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to aspirin or an NSAID (eg, ibuprofen, naproxen, celecoxib)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Diclofenac - Generic Voltaren/Misoprostol :

Some medical conditions may interact with Diclofenac - Generic Voltaren/Misoprostol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding

• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

• if you have allergies to medicines, foods, or other substances

• if you have a history of kidney or liver problems, the blood disease porphyria, bleeding problems, lupus, heart disease, ulcer problems, or high blood pressure

• if you have asthma; bone marrow depression; canker sores; or a hole, bleeding, or destruction of tissue in the stomach or intestines; or you are dehydrated

• if you drink alcohol

Some MEDICINES MAY INTERACT with Diclofenac - Generic Voltaren/Misoprostol. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine, paroxetine) because the risk of side effects, such as bleeding, may be increased

• Cyclosporine or methotrexate because the risk of toxicity may be increased

• Lithium because the risk of its side effects may be increased by Diclofenac - Generic Voltaren/Misoprostol

• Quinolone antibiotics (eg, ciprofloxacin) because the risk of side effects, such as seizures, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diclofenac - Generic Voltaren/Misoprostol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Diclofenac - Generic Voltaren/Misoprostol :

Use Diclofenac - Generic Voltaren/Misoprostol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Diclofenac - Generic Voltaren/Misoprostol comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Diclofenac - Generic Voltaren/Misoprostol refilled.

• Take Diclofenac - Generic Voltaren/Misoprostol by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

• Do not take magnesium-containing antacids while taking Diclofenac - Generic Voltaren/Misoprostol. If an antacid is needed, use one with calcium or aluminum.

• If you miss a dose of Diclofenac - Generic Voltaren/Misoprostol , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diclofenac - Generic Voltaren/Misoprostol.